Welcome To Website IAS

Hot news
Achievement

Independence Award

- First Rank - Second Rank - Third Rank

Labour Award

- First Rank - Second Rank -Third Rank

National Award

 - Study on food stuff for animal(2005)

 - Study on rice breeding for export and domestic consumption(2005)

VIFOTEC Award

- Hybrid Maize by Single Cross V2002 (2003)

- Tomato Grafting to Manage Ralstonia Disease(2005)

- Cassava variety KM140(2010)

Centres
Website links
Vietnamese calendar
Library
Visitors summary
 Curently online :  8
 Total visitors :  7362136

CRISPR-Cas12f1: A Mini Genome Editing Tool
Tuesday, 2021/11/30 | 07:09:37

ShanghaiTech University researchers and partners reported a genome editing tool called Cas12f1. Their findings are published in Nature Chemical Biology.

 

The RNA-guided CRISPR-associated (Cas) nucleases are handy tools for genome editing in different species. However, the large size of the commonly used Cas9 and Cas12 nucleases limits their application, especially for therapeutic purposes. Thus, the researchers developed a miniature class 2 type V-F CRISPR-Cas genome-editing system from Acidibacillus sulfuroxidans (AsCas12f1). According to the researchers, AsCas12f1 is an RNA-guided endonuclease that recognizes 5′ T-rich protospacer adjacent motifs and generates staggered double-stranded breaks to target DNA. It has been proven to be an effective genome editing tool in both bacteria and human cells using different delivery techniques such as plasmid, ribonucleoprotein, and adeno-associated virus.

 

Based on the findings, AsCas12f1 offers benefits in cellular delivery. This discovery could also help other researchers engineer more compact genome editing tools. In another paper, researchers from Pakistan's National Institute for Biotechnology and Genetic Engineering reported that the CRISPR-Cas12f1 system is also useful in developing transgene-free edited plants by deploying viral-based vectors and nanoparticles.

 

Read the abstracts in Nature Chemical Biology and Trends in Plant Science.

Back      Print      View: 197

[ Other News ]___________________________________________________
  • Beyond genes: Protein atlas scores nitrogen fixing duet
  • 2016 Borlaug CAST Communication Award Goes to Dr. Kevin Folta
  • FAO and NEPAD team up to boost rural youth employment in Benin, Cameroon, Malawi and Niger
  • Timely seed distributions in Ethiopia boost crop yields, strengthen communities’ resilience
  • Parliaments must work together in the final stretch against hunger
  • Empowering women farmers in the polder communities of Bangladesh
  • Depression: let’s talk
  • As APEC Concludes, CIP’s Food Security and Climate Smart Agriculture on Full Display
  • CIAT directly engages with the European Cocoa Industry
  • Breeding tool plays a key role in program planning
  • FAO: Transform Agriculture to Address Global Challenges
  • Uganda Holds Banana Research Training for African Scientists and Biotechnology Regulators
  • US Congress Ratifies Historic Global Food Security Treaty
  • Fruit Fly`s Genetic Code Revealed
  • Seminar at EU Parliament Tackles GM Crops Concerns
  • JICA and IRRI ignites a “seed revolution” for African and Asian farmers
  • OsABCG26 Vital in Anther Cuticle and Pollen Exine Formation in Rice
  • Akira Tanaka, IRRI’s first physiologist, passes away
  • WHO calls for immediate safe evacuation of the sick and wounded from conflict areas
  • Farmer Field School in Tonga continues to break new ground in the Pacific for training young farmers

 

Designed & Powered by WEBSO CO.,LTD