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Host and viral features of human dengue cases shape the population of infected and infectious Aedes aegypti mosquitoes
Thursday, 2013/05/30 | 08:08:38
  1. Nguyet Minh Nguyena,
  2. Duong Thi Hue Kiena,
  3. Trung Vu Tuana,
  4. Nguyen Than Ha Quyena,
  5. Chau N. B. Trana,
  6. Long Vo Thia,
  7. Dui Le Thia,
  8. Hoa Lan Nguyena,
  9. Jeremy J. Farrara,b,
  10. Edward C. Holmesc,d,
  11. Maia A. Rabaaa,
  12. Juliet E. Bryanta,b,
  13. Truong Thanh Nguyene,
  14. Huong Thi Cam Nguyene,
  15. Lan Thi Hong Nguyene,
  16. Mai Phuong Phame,
  17. Hung The Nguyene,
  18. Tai Thi Hue Luonge,
  19. Bridget Willsa,b,
  20. Chau Van Vinh Nguyene,
  21. Marcel Wolbersa,b, and
  22. Cameron P. Simmonsa,b,f,1


Author Affiliations


1.aOxford University Clinical Research Unit, District 5, Ho Chi Minh City, Vietnam;
2.bCentre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford OX1 2JD, United Kingdom;
3.cSydney Emerging Infections and Biosecurity Institute, School of Biological Sciences and Sydney Medical School, University of Sydney, Sydney, NSW 2006, Australia;
4.dFogarty International Center, National Institutes of Health, Bethesda, MD 20892;
5.eHospital for Tropical Diseases, District 5, Ho Chi Minh City, Vietnam; and
6.fNossal Institute for Global Health, University of Melbourne, VIC 3010, Australia
  1. Edited by Barry J. Beaty, Colorado State University, Fort Collins, CO, and approved April 15, 2013 (received for review February 25, 2013)




Dengue is the most prevalent arboviral disease of humans. The host and virus variables associated with dengue virus (DENV) transmission from symptomatic dengue cases (n = 208) to Aedes aegypti mosquitoes during 407 independent exposure events was defined. The 50% mosquito infectious dose for each of DENV-1–4 ranged from 6.29 to 7.52 log10 RNA copies/mL of plasma. Increasing day of illness, declining viremia, and rising antibody titers were independently associated with reduced risk of DENV transmission. High early DENV plasma viremia levels in patients were a marker of the duration of human infectiousness, and blood meals containing high concentrations of DENV were positively associated with the prevalence of infectious mosquitoes 14 d after blood feeding. Ambulatory dengue cases had lower viremia levels compared with hospitalized dengue cases but nonetheless at levels predicted to be infectious to mosquitoes. These data define serotype-specific viremia levels that vaccines or drugs must inhibit to prevent DENV transmission.



PNAS May 28, 2013 vol. 110 no. 22 9072-9077


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