Welcome To Website IAS

Hot news
Achievement

Independence Award

- First Rank - Second Rank - Third Rank

Labour Award

- First Rank - Second Rank -Third Rank

National Award

 - Study on food stuff for animal(2005)

 - Study on rice breeding for export and domestic consumption(2005)

VIFOTEC Award

- Hybrid Maize by Single Cross V2002 (2003)

- Tomato Grafting to Manage Ralstonia Disease(2005)

- Cassava variety KM140(2010)

Centres
Website links
Vietnamese calendar
Library
Visitors summary
 Curently online :  12
 Total visitors :  4972263

Superbug Slaying Antibiotics Increase Production by Tenfold With CRISPR-Cas9
Tuesday, 2021/01/19 | 08:18:06

Figure: Photo published by John Innes Centre from Dr Dino J. Martins, Executive Director of the Mpala Research Centre, Kenya, and a Research Scholar and Lecturer in Ecology and Evolutionary Biology at Princeton University.

 

Researchers from the John Innes Centre reported the successful increase in the production of a bacterial strain of Streptomyces formicae by 10 times using the genome editing technique CRISPR-Cas9. The findings can lead to further development in the research and production of antibiotics.

 

Streptomyces formicae bacterial strain is found in nests of species of the African ant. The ants use the antibiotic-producing bacteria to protect themselves and their food source from pathogens. Half of the existing antibiotics today are derived from formicamycin's specialized metabolites.

 

The researchers used CRISPR-Cas9 to make a strain that produced 10 times more formicamycins in laboratory conditions using agar plates and liquid cultures. Using the genome editing technique, they changed the regulatory genes by adding a copy of the forGF gene which responsible for the production of the useful compounds, and deleting the repressor gene for which is responsible for halting production. Once modified, they measured how much antibiotics were produced by the gene-edited strain. This also led to the production of different variations of formicamycins with antibiotic activity against superbugs such as methicillin-resistant Staphylococcus aureus (MRSA).

 

The researchers also emphasized that they will use the research to further investigate the regulation of formicamycin biosynthesis. They will use the over-producing strain that they developed to purify enough formicamycins and study their mode of action, how they kill superbugs like MRSA and why superbugs don't become resistant. Further research will allow them to understand how formicamycins work and determine if they have clinical development potential.

 

Read the full access paper in Cell Chemical Biology with reports from the John Innes Centre.

Back      Print      View: 36

[ Other News ]___________________________________________________
  • Beyond genes: Protein atlas scores nitrogen fixing duet
  • 2016 Borlaug CAST Communication Award Goes to Dr. Kevin Folta
  • FAO and NEPAD team up to boost rural youth employment in Benin, Cameroon, Malawi and Niger
  • Timely seed distributions in Ethiopia boost crop yields, strengthen communities’ resilience
  • Parliaments must work together in the final stretch against hunger
  • Empowering women farmers in the polder communities of Bangladesh
  • Depression: let’s talk
  • As APEC Concludes, CIP’s Food Security and Climate Smart Agriculture on Full Display
  • CIAT directly engages with the European Cocoa Industry
  • Breeding tool plays a key role in program planning
  • FAO: Transform Agriculture to Address Global Challenges
  • Uganda Holds Banana Research Training for African Scientists and Biotechnology Regulators
  • US Congress Ratifies Historic Global Food Security Treaty
  • Fruit Fly`s Genetic Code Revealed
  • Seminar at EU Parliament Tackles GM Crops Concerns
  • JICA and IRRI ignites a “seed revolution” for African and Asian farmers
  • OsABCG26 Vital in Anther Cuticle and Pollen Exine Formation in Rice
  • Akira Tanaka, IRRI’s first physiologist, passes away
  • WHO calls for immediate safe evacuation of the sick and wounded from conflict areas
  • Farmer Field School in Tonga continues to break new ground in the Pacific for training young farmers

 

Designed & Powered by WEBSO CO.,LTD