Welcome To Website IAS

Hot news
Achievement

Independence Award

- First Rank - Second Rank - Third Rank

Labour Award

- First Rank - Second Rank -Third Rank

National Award

 - Study on food stuff for animal(2005)

 - Study on rice breeding for export and domestic consumption(2005)

VIFOTEC Award

- Hybrid Maize by Single Cross V2002 (2003)

- Tomato Grafting to Manage Ralstonia Disease(2005)

- Cassava variety KM140(2010)

Centres
Website links
Vietnamese calendar
Library
Visitors summary
 Curently online :  10
 Total visitors :  4972136

The importance of microlipophagy in liver
Wednesday, 2021/01/13 | 08:23:00

Joel M. Goodman

PNAS January 12, 2021 118 (2) e2024058118

 

Cytoplasmic lipid droplets (LDs) store energy in the form of esterified fatty acids. Mobilization of those fatty acids can occur through cytosolic lipases that traffic to droplets, through lipophagy, or likely through LD contact sites with other organelles. Lipophagy, the degradation of LDs by lysosomes, has two forms: macrolipophagy, involving formation of autophagosomes, trapping LDs, that then fuse with lysosomes; and microlipophagy, in which LDs are directly engulfed by lysosomes. Macrolipophagy has been well described in liver, an organ in which LDs often accumulate in obesity and other disease states. The manuscript by Schulze et al. (1) in PNAS clearly shows that microlipophagy, a process well described in yeast, is a significant pathway in isolated hepatocytes and in liver in vivo. It is not difficult to imagine this is the tip of the iceberg and that the importance of microautophagic events in mammalian cells has been underappreciated until now.

 

See https://www.pnas.org/content/118/2/e2024058118

Figure: Pathways of LD digestion in liver cells. 1) Upon metabolic need, the size of LDs may first be reduced by cytosolic lipases initiated by adipocyte triglyceride lipase. They then are subjected to one of two autophagic pathways. 2a) Phagophore formation around LDs initiates macrolipophagy, resulting in fusion of the lipophagosome with a lysosome. 2b) Alternatively, as shown by Schulze et al. (1), an LD may be attracted directly to a lysosome, often resulting in macrolipophagy in which injection of LD contents into the lysosome occurs, or the entire LD is engulfed (not shown)

Back      Print      View: 36

[ Other News ]___________________________________________________
  • Egypt Holds Workshop on New Biotech Applications
  • UN Agencies Urge Transformation of Food Systems
  • Taiwan strongly supports management of brown planthopper—a major threat to rice production
  • IRRI Director General enjoins ASEAN states to invest in science for global food security
  • Rabies: Educate, vaccinate and eliminate
  • “As a wife I will help, manage, and love”: The value of qualitative research in understanding land tenure and gender in Ghana
  • CIP Director General Wells Reflects on CIP’s 45th Anniversary
  • Setting the record straight on oil palm and peat in SE Asia
  • Why insect pests love monocultures, and how plant diversity could change that
  • Researchers Modify Yeast to Show How Plants Respond to Auxin
  • GM Maize MIR162 Harvested in Large Scale Field Trial in Vinh Phuc, Vietnam
  • Conference Tackles Legal Obligations and Compensation on Biosafety Regulations in Vietnam
  • Iloilo Stakeholders Informed about New Biosafety Regulations in PH
  • Global wheat and rice harvests poised to set new record
  • GM Maize Harvested in Vietnam Field Trial Sites
  • New label for mountain products puts premium on biological and cultural diversity
  • The Nobel Prize in Physiology or Medicine 2016
  • Shalabh Dixit: The link between rice genes and rice farmers
  • People need affordable food, but prices must provide decent livelihoods for small-scale family farmers
  • GM Seeds Market Growth to Increase through 2020 Due to Rise in Biofuels Use

 

Designed & Powered by WEBSO CO.,LTD