Welcome To Website IAS

Hot news
Achievement

Independence Award

- First Rank - Second Rank - Third Rank

Labour Award

- First Rank - Second Rank -Third Rank

National Award

 - Study on food stuff for animal(2005)

 - Study on rice breeding for export and domestic consumption(2005)

VIFOTEC Award

- Hybrid Maize by Single Cross V2002 (2003)

- Tomato Grafting to Manage Ralstonia Disease(2005)

- Cassava variety KM140(2010)

Centres
Website links
Vietnamese calendar
Library
Visitors summary
 Curently online :  3
 Total visitors :  4447809

UPenn Develops Lettuce That Stimulates Bone Building Cells
Sunday, 2020/03/22 | 06:36:19

A team of scientists from the University of Pennsylvania's School of Dental Medicine developed lettuce plants that could stimulate the growth of bone-building cells and promote bone regeneration by using an animal protein to synthesize an orally delivered shelf-stable medication grown in the lettuce. This can address the medication needs of bone-fracture and diabetic patients who can have the option of eating their medicine rather than use injectables.

 

The scientists inserted the DNA of a protein called the Insulin-like Growth Factor 1 or IGF-1 into the lettuce genome. IGF-1 is an animal protein that can pass through the stomach and be absorbed in the gut. The protein is known to signal the increase in the number and longevity of the cells responsible for bone growth promoting fracture healing, and dental tissue regeneration. This is particularly important for older adults who are at risk for fracture, and also for diabetics who have low IGF-1 levels. Diabetic patients are prone to bone fractures more than the general public and are known to heal slower. Though there are existing treatments to address this, patients often skip them because they are expensive and require a repetitive process of injections.

 

The developed lettuce was grown in the laboratory and later on was put to the test by feeding it to diabetic mice with broken bones. Results showed that the mice had an increase of IGF-1 levels in their bloodstream and it stayed that way for a few hours. Further testing showed that the mice had a significant increase in bone volume and density at their fracture sites. The scientists also found that the lettuce leaves can be freeze-dried and ground into powder form and is shelf-stable for nearly three years.

 

This new development can become an option for diabetic patients with bone fractures. Instead of seeking treatment using repetitive injectables with a short shelf-life span that need to be refrigerated, it is possible to produce a plant-based solution, in this case, the lettuce, that can be eaten, stored and transported at room temperature, and can be grown, thus qualifying as a renewable resource of the medication.

 

The scientists published the results of their study in Biomaterials.

 

Figure: Generation of lettuce/tobacco transplastomic lines expressing codon-optimized CTB-Pro-IGF-1 gene. (A) Schematic illustration of CTB-Pro-IGF-1 expression cassette for lettuce chloroplast transformation. (A and E) 16s rRNA and 23s rRNA, 16s and 23s ribosomal RNA; trnI, isoleucyl-tRNA; trnA, alanyl-tRNA; Prrn, rRNA operon promoter; aadA, aminoglycoside 3′-adenylytransferase; TrbcL, 3′ UTR of ribulose bisphosphate carboxylase large subunit; PpsbA, promoter of psbA; CTB-Pro-IGF-1(co), codon optimized premature form of human insulin-like growth factor-1 with CTB (Cholera non-toxic B subunit) fusion; TpsbA, 3′-UTR of psbA; SB-P, Southern blot probe. Primer sets used for PCR screening are indicated in arrows. (B) Genomic DNA PCR screening, (C) Southern blot analysis, and (D) Protein expressions of the lettuce lines expressing CTB-Pro-IGF-1. Expected sizes are indicated in arrows (24.3 kDa). (BD) Lanes 1 to 4, individual transplastomic lines; WT, untransformed wild type; LS, lettuce. (E) Schematic illustration of CTB-Pro-IGF-1 expression cassette for tobacco chloroplast transformation. (F) Southern blot analysis of CTB-Pro-IGF1 tobacco transplastomic lines. WT, untransformed wild type; lanes 1 and 2, transplastomic lines; PH, tobacco Petit Havana.

Back      Print      View: 37

[ Other News ]___________________________________________________
  • Egypt Holds Workshop on New Biotech Applications
  • UN Agencies Urge Transformation of Food Systems
  • Taiwan strongly supports management of brown planthopper—a major threat to rice production
  • IRRI Director General enjoins ASEAN states to invest in science for global food security
  • Rabies: Educate, vaccinate and eliminate
  • “As a wife I will help, manage, and love”: The value of qualitative research in understanding land tenure and gender in Ghana
  • CIP Director General Wells Reflects on CIP’s 45th Anniversary
  • Setting the record straight on oil palm and peat in SE Asia
  • Why insect pests love monocultures, and how plant diversity could change that
  • Researchers Modify Yeast to Show How Plants Respond to Auxin
  • GM Maize MIR162 Harvested in Large Scale Field Trial in Vinh Phuc, Vietnam
  • Conference Tackles Legal Obligations and Compensation on Biosafety Regulations in Vietnam
  • Iloilo Stakeholders Informed about New Biosafety Regulations in PH
  • Global wheat and rice harvests poised to set new record
  • GM Maize Harvested in Vietnam Field Trial Sites
  • New label for mountain products puts premium on biological and cultural diversity
  • The Nobel Prize in Physiology or Medicine 2016
  • Shalabh Dixit: The link between rice genes and rice farmers
  • People need affordable food, but prices must provide decent livelihoods for small-scale family farmers
  • GM Seeds Market Growth to Increase through 2020 Due to Rise in Biofuels Use
Designed & Powered by WEBSO CO.,LTD