Welcome To Website IAS

Hot news
Achievement

Independence Award

- First Rank - Second Rank - Third Rank

Labour Award

- First Rank - Second Rank -Third Rank

National Award

 - Study on food stuff for animal(2005)

 - Study on rice breeding for export and domestic consumption(2005)

VIFOTEC Award

- Hybrid Maize by Single Cross V2002 (2003)

- Tomato Grafting to Manage Ralstonia Disease(2005)

- Cassava variety KM140(2010)

Centres
Website links
Vietnamese calendar
Library
Visitors summary
 Curently online :  3
 Total visitors :  5123069

MIT and UCSF Researchers Create On and Off Switch for CRISPR
Saturday, 2021/04/17 | 05:21:51

CRISPER has just got better with the latest gene editing technology called CRISPRoff. Researchers from the Massachusetts Institute of Technology and the University of California, San Francisco (UCSF) described the new reversible CRISPR method in the Cell journal.

 

Since its discovery, CRISPR-Cas9 has revolutionized genetic engineering by enabling researchers to make targeted modifications in the DNA. However, CRISPR-Cas9 involved cutting DNA strands, which can lead to permanent changes in the genetic material. With CRISPRoff, researchers can regulate gene expression with high specificity without changing the DNA of the organism. Such modifications, which are called "epigenetic gene silencing" become effective through methylation, which involves adding chemical tags to specific locations in the DNA. When tagged, the DNA portion becomes unreachable to RNA polymerase, which reads the genetic data in the DNA into mRNA transcripts that serve as blueprints for proteins.

 

The researchers developed a tiny protein machine that can tack methyl groups onto certain locations on the DNA strand. The methylated genes become silenced or switched off, thus the name CRISPRoff. Since the DNA strand is not changed, the researchers can reverse the silencing effect with the use of enzymes that remove methyl groups, a technique they dubbed as CRISPRon.

 

Read the press release in SciTech Daily and the research article in Cell for more information.

Back      Print      View: 21

[ Other News ]___________________________________________________
  • Egypt Holds Workshop on New Biotech Applications
  • UN Agencies Urge Transformation of Food Systems
  • Taiwan strongly supports management of brown planthopper—a major threat to rice production
  • IRRI Director General enjoins ASEAN states to invest in science for global food security
  • Rabies: Educate, vaccinate and eliminate
  • “As a wife I will help, manage, and love”: The value of qualitative research in understanding land tenure and gender in Ghana
  • CIP Director General Wells Reflects on CIP’s 45th Anniversary
  • Setting the record straight on oil palm and peat in SE Asia
  • Why insect pests love monocultures, and how plant diversity could change that
  • Researchers Modify Yeast to Show How Plants Respond to Auxin
  • GM Maize MIR162 Harvested in Large Scale Field Trial in Vinh Phuc, Vietnam
  • Conference Tackles Legal Obligations and Compensation on Biosafety Regulations in Vietnam
  • Iloilo Stakeholders Informed about New Biosafety Regulations in PH
  • Global wheat and rice harvests poised to set new record
  • GM Maize Harvested in Vietnam Field Trial Sites
  • New label for mountain products puts premium on biological and cultural diversity
  • The Nobel Prize in Physiology or Medicine 2016
  • Shalabh Dixit: The link between rice genes and rice farmers
  • People need affordable food, but prices must provide decent livelihoods for small-scale family farmers
  • GM Seeds Market Growth to Increase through 2020 Due to Rise in Biofuels Use

 

Designed & Powered by WEBSO CO.,LTD