Welcome To Website IAS

Hot news

Independence Award

- First Rank - Second Rank - Third Rank

Labour Award

- First Rank - Second Rank -Third Rank

National Award

 - Study on food stuff for animal(2005)

 - Study on rice breeding for export and domestic consumption(2005)


- Hybrid Maize by Single Cross V2002 (2003)

- Tomato Grafting to Manage Ralstonia Disease(2005)

- Cassava variety KM140(2010)

Website links
Vietnamese calendar
Visitors summary
 Curently online :  3
 Total visitors :  6728634

Chromosome Engineering Now Possible in Mammals
Tuesday, 2022/09/27 | 08:27:59

Previous attempts in chromosome engineering were only successful in yeast, but scientists in China were able to produce the first sustainable engineered karyotype on laboratory mice which now carries two chromosomes fused together.


To achieve this, the scientists fused the two largest mouse chromosomes, labeled chromosomes 1 and 2, and two medium-size chromosomes, labeled chromosomes 4 and 5, using haploid embryonic stem cells and gene editing to program the chromosome ligation in mice and create new karyotypes. In the process, the scientists noted the difficulty in deriving stem cells from unfertilized mouse embryos since the cells only contain one set of chromosomes. But through the concept of genomic imprinting, they figured out that by deleting three naturally imprinted regions, a stable, sperm-like imprinting pattern in cells can be established. This allowed them to fuse chromosomes 4 and 5 head to tail with chromosomes 1 and 2 and create karyotypes in three different arrangements without significantly affecting chromatin conformation and sent cell differentiation. Further testing led to karyotypes carrying fused chromosomes 1 and 2, which resulted in arrested mitosis, polyploidization, and embryonic lethality. On the other hand, a smaller fused chromosome composed of chromosomes 4 and 5 was able to be passed on to homozygous offspring.


This feat allowed a better understanding of how misaligned or malformed chromosomes can be corrected through chromosome engineering in mammals. It also demonstrated that the chromosomal rearrangement event is the basis for species evolution and its importance to reproductive isolation. These findings can unlock possibilities for large-scale DNA engineering in mammals.


More details can be found in Science and EurekAlert!



Back      Print      View: 120

[ Other News ]___________________________________________________
  • Beyond genes: Protein atlas scores nitrogen fixing duet
  • 2016 Borlaug CAST Communication Award Goes to Dr. Kevin Folta
  • FAO and NEPAD team up to boost rural youth employment in Benin, Cameroon, Malawi and Niger
  • Timely seed distributions in Ethiopia boost crop yields, strengthen communities’ resilience
  • Parliaments must work together in the final stretch against hunger
  • Empowering women farmers in the polder communities of Bangladesh
  • Depression: let’s talk
  • As APEC Concludes, CIP’s Food Security and Climate Smart Agriculture on Full Display
  • CIAT directly engages with the European Cocoa Industry
  • Breeding tool plays a key role in program planning
  • FAO: Transform Agriculture to Address Global Challenges
  • Uganda Holds Banana Research Training for African Scientists and Biotechnology Regulators
  • US Congress Ratifies Historic Global Food Security Treaty
  • Fruit Fly`s Genetic Code Revealed
  • Seminar at EU Parliament Tackles GM Crops Concerns
  • JICA and IRRI ignites a “seed revolution” for African and Asian farmers
  • OsABCG26 Vital in Anther Cuticle and Pollen Exine Formation in Rice
  • Akira Tanaka, IRRI’s first physiologist, passes away
  • WHO calls for immediate safe evacuation of the sick and wounded from conflict areas
  • Farmer Field School in Tonga continues to break new ground in the Pacific for training young farmers


Designed & Powered by WEBSO CO.,LTD