Welcome To Website IAS

Hot news
Achievement

Independence Award

- First Rank - Second Rank - Third Rank

Labour Award

- First Rank - Second Rank -Third Rank

National Award

 - Study on food stuff for animal(2005)

 - Study on rice breeding for export and domestic consumption(2005)

VIFOTEC Award

- Hybrid Maize by Single Cross V2002 (2003)

- Tomato Grafting to Manage Ralstonia Disease(2005)

- Cassava variety KM140(2010)

Centres
Website links
Vietnamese calendar
Library
Visitors summary
 Curently online :  23
 Total visitors :  7651475

Evolutionary paths of least resistance
Monday, 2015/10/19 | 15:39:30

Claus O. Wilke

Department of Integrative Biology, The University of Texas at Austin, Austin, TX 78712
When organisms face a challenging environment, they may respond by adapting along different potential evolutionary paths. Each potential path will likely correspond to a different biological mechanism for fitness increase, and which of these alternative mechanisms will evolve depends on a number of factors, including the relative fitness benefits and costs of a given mechanism, the number and type of mutations necessary to evolve the mechanism, and random chance. If one of these evolutionary paths is consistently chosen over the others, then we can think of it as the path of least resistance. In PNAS, Bratulic et al. (1) study the evolutionary paths of least resistance in Escherichia coli bacteria exposed to the antibiotic ampicillin. The authors study E. coli strains carrying a plasmid expressing TEM-1, a protein that confers resistance to ampicillin. The experimental strain has an elevated rate of translation errors, whereas a control strain has a normal translational error rate. The experiment is set up such that only the coding sequence of TEM-1 can evolve, but not the E. coli strains themselves nor the rest of the plasmid. Bratulic et al. find that under an elevated translational error rate, the path of least resistance is to evolve reduced translation-initiation efficiency for TEM-1 when ampicillin concentration is low, and robustness to translation errors when ampicillin concentration is high (Fig. 1). In contrast, a reduction in translational error rate, which could have evolved through modified synonymous choice, is not observed.

See http://www.pnas.org/content/112/41/12553.extract.html?etoc
Back      Print      View: 845

[ Other News ]___________________________________________________
  • Egypt Holds Workshop on New Biotech Applications
  • UN Agencies Urge Transformation of Food Systems
  • Taiwan strongly supports management of brown planthopper—a major threat to rice production
  • IRRI Director General enjoins ASEAN states to invest in science for global food security
  • Rabies: Educate, vaccinate and eliminate
  • “As a wife I will help, manage, and love”: The value of qualitative research in understanding land tenure and gender in Ghana
  • CIP Director General Wells Reflects on CIP’s 45th Anniversary
  • Setting the record straight on oil palm and peat in SE Asia
  • Why insect pests love monocultures, and how plant diversity could change that
  • Researchers Modify Yeast to Show How Plants Respond to Auxin
  • GM Maize MIR162 Harvested in Large Scale Field Trial in Vinh Phuc, Vietnam
  • Conference Tackles Legal Obligations and Compensation on Biosafety Regulations in Vietnam
  • Iloilo Stakeholders Informed about New Biosafety Regulations in PH
  • Global wheat and rice harvests poised to set new record
  • GM Maize Harvested in Vietnam Field Trial Sites
  • New label for mountain products puts premium on biological and cultural diversity
  • The Nobel Prize in Physiology or Medicine 2016
  • Shalabh Dixit: The link between rice genes and rice farmers
  • People need affordable food, but prices must provide decent livelihoods for small-scale family farmers
  • GM Seeds Market Growth to Increase through 2020 Due to Rise in Biofuels Use

 

Designed & Powered by WEBSO CO.,LTD