Welcome To Website IAS

Hot news
Achievement

Independence Award

- First Rank - Second Rank - Third Rank

Labour Award

- First Rank - Second Rank -Third Rank

National Award

 - Study on food stuff for animal(2005)

 - Study on rice breeding for export and domestic consumption(2005)

VIFOTEC Award

- Hybrid Maize by Single Cross V2002 (2003)

- Tomato Grafting to Manage Ralstonia Disease(2005)

- Cassava variety KM140(2010)

Centres
Website links
Vietnamese calendar
Library
Visitors summary
 Curently online :  23
 Total visitors :  7660313

Structural analysis reveals vulnerability in Junín virus
Saturday, 2017/07/01 | 06:25:29

Figure: Structure of JUNV GP1 in complex with OD01.

 

Junín virus, a New World arenavirus carried by rodent populations in rural Argentina, causes the deadly Argentine hemorrhagic fever in humans. Although researchers estimate that around 5 million people are at risk of contracting Junín virus (JUNV), no internationally approved drugs are currently available to prevent or treat infection by this zoonotic pathogen. Extending previous studies aimed at understanding the antibody-mediated immune response to JUNV infection, Antra Zeltina et al. performed a structural analysis, revealing that a mouse-derived neutralizing antibody, OD01, disrupts the activity of a glycoprotein spike complex on the surface of JUNV that allows the virus to recognize and enter a host cell. Furthermore, the authors show that the antibody action of OD01 is similar to that of a previously reported mouse-derived neutralizing antibody, GD01; both immunoglobulins use a tyrosine residue to mimic a critical contact made by the JUNV glycoprotein receptor. The latter finding demonstrates that both antibodies converge on the same immunological mode of attack, thus revealing a key vulnerability in JUNV surface. The findings could aid the generation of neutralizing antibodies that target the JUNV glycoprotein surface, according to the authors. — T.J.

 

SEE: http://www.pnas.org/site/highlights/highlights.xhtml#structural

Back      Print      View: 443

[ Other News ]___________________________________________________
  • Egypt Holds Workshop on New Biotech Applications
  • UN Agencies Urge Transformation of Food Systems
  • Taiwan strongly supports management of brown planthopper—a major threat to rice production
  • IRRI Director General enjoins ASEAN states to invest in science for global food security
  • Rabies: Educate, vaccinate and eliminate
  • “As a wife I will help, manage, and love”: The value of qualitative research in understanding land tenure and gender in Ghana
  • CIP Director General Wells Reflects on CIP’s 45th Anniversary
  • Setting the record straight on oil palm and peat in SE Asia
  • Why insect pests love monocultures, and how plant diversity could change that
  • Researchers Modify Yeast to Show How Plants Respond to Auxin
  • GM Maize MIR162 Harvested in Large Scale Field Trial in Vinh Phuc, Vietnam
  • Conference Tackles Legal Obligations and Compensation on Biosafety Regulations in Vietnam
  • Iloilo Stakeholders Informed about New Biosafety Regulations in PH
  • Global wheat and rice harvests poised to set new record
  • GM Maize Harvested in Vietnam Field Trial Sites
  • New label for mountain products puts premium on biological and cultural diversity
  • The Nobel Prize in Physiology or Medicine 2016
  • Shalabh Dixit: The link between rice genes and rice farmers
  • People need affordable food, but prices must provide decent livelihoods for small-scale family farmers
  • GM Seeds Market Growth to Increase through 2020 Due to Rise in Biofuels Use

 

Designed & Powered by WEBSO CO.,LTD