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| High-dimensional multi-omics measured in controlled conditions are useful for maize platform and field trait predictions |
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The effects of climate change in the form of drought, heat stress, and irregular seasonal changes threaten global crop production. The ability of multi-omics data, such as transcripts and proteins, to reflect a plant’s response to such climatic factors can be capitalized in prediction models to maximize crop improvement. Implementing multi-omics characterization in field evaluations is challenging due to high costs. |
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Baber Ali, Bertrand Huguenin-Bizot, Maxime Laurent, François Chaumont, Laurie C. Maistriaux, Stéphane Nicolas, Hervé Duborjal, Claude Welcker, François Tardieu, Tristan Mary-Huard, Laurence Moreau, Alain Charcosset, Daniel Runcie & Renaud Rincent Theoretical and Applied Genetics; July 2024; vol.137; article 175
Figure: Maize Field Crop Key messageTranscriptomics and proteomics information collected on a platform can predict additive and non-additive effects for platform traits and additive effects for field traits. AbstractThe effects of climate change in the form of drought, heat stress, and irregular seasonal changes threaten global crop production. The ability of multi-omics data, such as transcripts and proteins, to reflect a plant’s response to such climatic factors can be capitalized in prediction models to maximize crop improvement. Implementing multi-omics characterization in field evaluations is challenging due to high costs. It is, however, possible to do it on reference genotypes in controlled conditions. Using omics measured on a platform, we tested different multi-omics-based prediction approaches, using a high dimensional linear mixed model (MegaLMM) to predict genotypes for platform traits and agronomic field traits in a panel of 244 maize hybrids. We considered two prediction scenarios: in the first one, new hybrids are predicted (CV-NH), and in the second one, partially observed hybrids are predicted (CV-POH). For both scenarios, all hybrids were characterized for omics on the platform. We observed that omics can predict both additive and non-additive genetic effects for the platform traits, resulting in much higher predictive abilities than GBLUP. It highlights their efficiency in capturing regulatory processes in relation to growth conditions. For the field traits, we observed that the additive components of omics only slightly improved predictive abilities for predicting new hybrids (CV-NH, model MegaGAO) and for predicting partially observed hybrids (CV-POH, model GAOxW-BLUP) in comparison to GBLUP. We conclude that measuring the omics in the fields would be of considerable interest in predicting productivity if the costs of omics drop significantly.
See https://link.springer.com/article/10.1007/s00122-024-04679-w
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