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Researchers Develop First Gene Drive Targeting Worldwide Crop Pest.
Tuesday, 2018/04/24 | 07:52:24
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UC San Diego News Center, April 17, 2018
Innovation establishes method to control invasive fly that deposits eggs in fruit crops, causing millions in damage.
Biologists at the University of California San Diego have developed a method of manipulating the genes of an agricultural pest that has invaded much of the United States and caused millions of dollars in damage to high-value berry and other fruit crops.
Research led by Anna Buchman in the lab of Omar Akbari, a new UC San Diego insect genetics professor, describes the world’s first “gene drive” system—a mechanism for manipulating genetic inheritance—in Drosophila suzukii, a fruit fly commonly known as the spotted-wing drosophila.
As reported April 17 in the Proceedings of the National Academy of Sciences, Buchman and her colleagues developed a gene drive system termed Medea (named after the mythological Greek enchantress who killed her offspring) in which a synthetic “toxin” and a corresponding “antidote” function to dramatically influence inheritance rates with nearly perfect efficiency.
“We’ve designed a gene drive system that dramatically biases inheritance in these flies and can spread through their populations,” said Buchman. “It bypasses normal inheritance rules. It’s a new method for manipulating populations of these invasive pests, which don’t belong here in the first place.”
Native to Japan, the highly invasive fly was first found on the West Coast in 2008 and has now been reported in more than 40 states. The spotted wing drosophila uses a sharp organ known as an ovipositor to pierce ripening fruit and deposit eggs directly inside the crop, making it much more damaging than other drosophila flies that lay eggs only on top of decaying fruit. Drosophila suzukii has reportedly caused more than $39 million in revenue losses for the California raspberry industry alone and an estimated $700 million overall per year in the U.S.
In contained cage experiments of spotted wing drosophila using the synthetic Medea system, the researchers reported up to 100 percent effective inheritance bias in populations descending 19 generations.
“We envision, for example, replacing wild flies with flies that are alive but can’t lay eggs directly in blueberries,” said Buchman.
Applications for the new synthetic gene drive system could include spreading genetic elements that confer susceptibility to certain environmental factors, such as temperature. If a certain temperature is reached, for example, the genes within the modified spotted wing flies would trigger its death. Other species of fruit flies would not be impacted by this system.
Figure: In the past 10 years, the invasive fruit fly known as the spotted-wing drosophila (Drosophila suzukii) has caused millions of dollars of damage to berry and other fruit crops. Credit: Michelle Bui, UC San Diego |
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