Welcome To Website IAS

Hot news
Achievement

Independence Award

- First Rank - Second Rank - Third Rank

Labour Award

- First Rank - Second Rank -Third Rank

National Award

 - Study on food stuff for animal(2005)

 - Study on rice breeding for export and domestic consumption(2005)

VIFOTEC Award

- Hybrid Maize by Single Cross V2002 (2003)

- Tomato Grafting to Manage Ralstonia Disease(2005)

- Cassava variety KM140(2010)

Centres
Website links
Vietnamese calendar
Library
Visitors summary
 Curently online :  20
 Total visitors :  7948065

In fatal COVID-19, the immune response can control the virus but kill the patient
Tuesday, 2020/12/08 | 09:05:24

Arturo Casadevall and Liise-anne Pirofski

PNAS December 1, 2020 117 (48) 30009-30011

 

Fig.: Prof. Arturo Casadevall; Johns Hopskins Medecine

 

COVID-19 is often a biphasic illness with an initial phase of upper respiratory symptoms that can rapidly progress to profound hypoxemia and respiratory failure. Postmortem studies of severe COVID-19 reveal diffuse alveolar damage, hyaline membranes, and thrombi, with varying degrees of inflammation and types of cellular infiltrates. Now, with their autopsy study of early victims of the pandemic in China, Wu et al. (6) provide important insights into the inflammatory pathways that lead to severe COVID-19 pneumonia. Their extensive transcriptional and proteomic analyses of lung tissue from patients with severe pneumonia reveal signatures indicative of a neutrophil-driven inflammatory response without evidence of much active viral proliferation. These findings indicate that the pathogenesis of late severe COVID-19 pneumonia involves a dysregulated immune response, rather than direct viral damage.

In summary, Wu et al. (6) provide insights reinforcing the critical point that, despite controlling the virus, the immune response may also result in irreparable damage that is fatal. Although this notion was already part of the emerging understanding of the pathogenesis of this disease (1), firm evidence from autopsy studies demonstrating that people die with inflammation and a very low viral load moves this concept from hypothesis to fact, with great consequences for directing clinical care and designing new therapies.

 

See more https://www.pnas.org/content/117/48/30009

Figure:

Proposed scheme for the progression and outcomes of COVID-19 from the viewpoint of the damage−response of pathogenesis (24). According to the damage−response framework, the relevant outcome is the amount of host damage endured by the host during the host−microbe interaction. Considering damage as a function of time, death occurs in those individuals who suffer irreparable tissue damage, which appears to be mediated largely by the inflammatory response to SARS-Cov-2.

Back      Print      View: 202

[ Other News ]___________________________________________________
  • Egypt Holds Workshop on New Biotech Applications
  • UN Agencies Urge Transformation of Food Systems
  • Taiwan strongly supports management of brown planthopper—a major threat to rice production
  • IRRI Director General enjoins ASEAN states to invest in science for global food security
  • Rabies: Educate, vaccinate and eliminate
  • “As a wife I will help, manage, and love”: The value of qualitative research in understanding land tenure and gender in Ghana
  • CIP Director General Wells Reflects on CIP’s 45th Anniversary
  • Setting the record straight on oil palm and peat in SE Asia
  • Why insect pests love monocultures, and how plant diversity could change that
  • Researchers Modify Yeast to Show How Plants Respond to Auxin
  • GM Maize MIR162 Harvested in Large Scale Field Trial in Vinh Phuc, Vietnam
  • Conference Tackles Legal Obligations and Compensation on Biosafety Regulations in Vietnam
  • Iloilo Stakeholders Informed about New Biosafety Regulations in PH
  • Global wheat and rice harvests poised to set new record
  • GM Maize Harvested in Vietnam Field Trial Sites
  • New label for mountain products puts premium on biological and cultural diversity
  • The Nobel Prize in Physiology or Medicine 2016
  • Shalabh Dixit: The link between rice genes and rice farmers
  • People need affordable food, but prices must provide decent livelihoods for small-scale family farmers
  • GM Seeds Market Growth to Increase through 2020 Due to Rise in Biofuels Use

 

Designed & Powered by WEBSO CO.,LTD